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BMS-265246

BMS-265246

Name: BMS-265246
Brand: Adooq Bioscience
SKU: A11154
Rating: 100 (268 reviews)

Catalog No.: A11154

CDK inhibitor

BMS-265246 Chemical Structure

CAS NO. 582315-72-8

BMS-265246 is a potent new pyra- zolopyridine inhibitor of cdk2/cyclin E and cdk1/cyclin B, as well as cdk4/cyclin D.

Availability: In stock

Package	Price	Qty
5 mg	$180.00
10 mg	$300.00
50 mg	$800.00
100 mg	$1,400.00
10mM * 1mL in DMSO	$197.00
Custom Size	Get quote

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Biological Activity

BMS-265246 is a potent new pyra- zolopyridine inhibitor of cdk2/cyclin E and cdk1/cyclin B, as well as cdk4/cyclin D.

Targets

CDK1/CyclinB (Cell-free assay)	CDK2/CyclinE (Cell-free assay)	CDK4/CyclinD (Cell-free assay)
6 nM	9 nM	230 nM

Solubility *

In vitro (25°C)	DMSO	18 mg/mL (52.12 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.96 mL	144.8 mL	289.6 mL
0.5 mM	5.79 mL	28.96 mL	57.92 mL
1 mM	2.9 mL	14.48 mL	28.96 mL
5 mM	0.58 mL	2.9 mL	5.79 mL

*The above data is based on the productmolecular weight 345.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11154
Actions	Inhibitor
CAS No.	582315-72-8
Formula	C18H17F2N3O2
M. Wt	345.3
Purity	>98%
Synonyms	BMS265246
SMILES	CCCCOC1=C2C=NNC2=NC=C1C(=O)C3=C(C=C(C=C3F)C)F
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.