Catalog No.: A11154

CDK inhibitor


BMS-265246 Chemical Structure

CAS NO. 582315-72-8

BMS-265246 is a potent new pyra- zolopyridine inhibitor of cdk2/cyclin E and cdk1/cyclin B, as well as cdk4/cyclin D.

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Biological Activity

BMS-265246 is a potent new pyra- zolopyridine inhibitor of cdk2/cyclin E and cdk1/cyclin B, as well as cdk4/cyclin D.
CDK1/CyclinB (Cell-free assay) CDK2/CyclinE (Cell-free assay) CDK4/CyclinD (Cell-free assay)
6 nM9 nM230 nM
In vitro (25°C) DMSO 18 mg/mL (52.12 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.96 mL 144.8 mL 289.6 mL
0.5 mM 5.79 mL 28.96 mL 57.92 mL
1 mM 2.9 mL 14.48 mL 28.96 mL
5 mM 0.58 mL 2.9 mL 5.79 mL

*The above data is based on the productmolecular weight 345.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11154
Actions Inhibitor
CAS No. 582315-72-8
Formula C18H17F2N3O2
M. Wt 345.3
Purity >98%
Synonyms BMS265246

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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