BMS-536924

Catalog No.: A11054

IGF-1R inhibitor

BMS-536924

BMS-536924 Chemical Structure

CAS NO. 468740-43-4

BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.

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5 mg

Regular Price: $75.00

Special Price $60.00

10 mg

Regular Price: $130.00

Special Price $104.00

50 mg

Regular Price: $500.00

Special Price $400.00

100 mg

Regular Price: $750.00

Special Price $600.00

10mM * 1mL in DMSO

Regular Price: $120.00

Special Price $96.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Qiao Zhou, .et al. BMS-536924, an ATP-competitive IGF-1R/IR inhibitor, decreases viability and migration of temozolomide-resistant glioma cells in vitro and suppresses tumor growth in vivo, Onco Targets Ther., 2015, 8: 689-697 PMID: 25897243

Biological Activity

BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.
Targets
Target Value
Insulin ReceptorIC50: 73nM
IGF-1RIC50: 100nM
FAKIC50: 150nM
MEKIC50: 182nM
LCKIC50: 341nM
CDK2/CyclinEIC50: >1μM
VEGFR2IC50: 1.4μM
EGFIC50: 1.6μM
MetIC50: 4.87μM
MAPK2IC50: ~5μM
MAPK1IC50: >5μM
Akt1IC50: >5μM
PDGFRIC50: >5μM
HER2IC50: 17.1μM
In vitro (25°C) DMSO 92 mg/mL (191.68 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.83 mL 104.17 mL 208.33 mL
0.5 mM 4.17 mL 20.83 mL 41.67 mL
1 mM 2.08 mL 10.42 mL 20.83 mL
5 mM 0.42 mL 2.08 mL 4.17 mL

*The above data is based on the productmolecular weight 480.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11054
Actions Inhibitor
CAS No. 468740-43-4
Formula C25H26ClN5O3
M. Wt 480.0
Purity >98%
Synonyms BMS536924
SMILES CC1=CC(=CC2=C1N/C(=C/3\C(=CC=NC3=O)NC[[email protected]](C4=CC(=CC=C4)Cl)O)/N2)N5CCOCC5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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