BMS-536924

Name: BMS-536924
Brand: Adooq Bioscience
SKU: A11054
Rating: 100 (1 reviews)

Catalog No.: A11054

IGF-1R inhibitor

Product Citations (1)

BMS-536924 Chemical Structure

CAS NO. 468740-43-4

BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.

Availability: In stock

Package	Price	Qty
5 mg	Regular Price: $75.00 Special Price $60.00
10 mg	Regular Price: $130.00 Special Price $104.00
50 mg	Regular Price: $500.00 Special Price $400.00
100 mg	Regular Price: $750.00 Special Price $600.00
10mM * 1mL in DMSO	Regular Price: $120.00 Special Price $96.00
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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq BMS-536924

Qiao Zhou, .et al. BMS-536924, an ATP-competitive IGF-1R/IR inhibitor, decreases viability and migration of temozolomide-resistant glioma cells in vitro and suppresses tumor growth in vivo, Onco Targets Ther., 2015, 8: 689-697 PMID: 25897243

Biological Activity

BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.

Targets

Target	Value
Insulin Receptor	IC50: 73nM
IGF-1R	IC50: 100nM
FAK	IC50: 150nM
MEK	IC50: 182nM
LCK	IC50: 341nM
CDK2/CyclinE	IC50: >1μM
VEGFR2	IC50: 1.4μM
EGF	IC50: 1.6μM
Met	IC50: 4.87μM
MAPK2	IC50: ~5μM
MAPK1	IC50: >5μM
Akt1	IC50: >5μM
PDGFR	IC50: >5μM
HER2	IC50: 17.1μM

Solubility *

In vitro (25°C)	DMSO	92 mg/mL (191.68 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.83 mL	104.17 mL	208.33 mL
0.5 mM	4.17 mL	20.83 mL	41.67 mL
1 mM	2.08 mL	10.42 mL	20.83 mL
5 mM	0.42 mL	2.08 mL	4.17 mL

*The above data is based on the productmolecular weight 480.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11054
Actions	Inhibitor
CAS No.	468740-43-4
Formula	C25H26ClN5O3
M. Wt	480.0
Purity	>98%
Synonyms	BMS536924
SMILES	CC1=CC(=CC2=C1N/C(=C/3\C(=CC=NC3=O)NC[[email protected]](C4=CC(=CC=C4)Cl)O)/N2)N5CCOCC5
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.