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IGF-1R inhibitor

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Catalog No. A11054

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BMS-536924 5mg A11054-5
BMS-536924 10mg A11054-10
BMS-536924 50mg A11054-50
BMS-536924 100mg A11054-100
BMS-536924 10mM * 1mL in DMSO A11054-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.


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Publications citing Adooq Products
BMS-536924 Citations (1)
  • Qiao Zhou, .et al. BMS-536924, an ATP-competitive IGF-1R/IR inhibitor, decreases viability and migration of temozolomide-resistant glioma cells in vitro and suppresses tumor growth in vivo, Onco Targets Ther., 2015, 8: 689-697 PMID: 25897243

Chemical Information

Catalog Num A11054
Actions Inhibitor
M. Wt 480.0
Formula C25H26ClN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 468740-43-4
Synonyms BMS536924
SMILES CC1=CC(=CC2=C1N/C(=C/3\C(=CC=NC3=O)NC[[email protected]](C4=CC(=CC=C4)Cl)O)/N2)N5CCOCC5

Biological Activity

BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.
Target Value
Insulin ReceptorIC50: 73nM
IGF-1RIC50: 100nM
FAKIC50: 150nM
MEKIC50: 182nM
LCKIC50: 341nM
CDK2/CyclinEIC50: >1μM
VEGFR2IC50: 1.4μM
EGFIC50: 1.6μM
MetIC50: 4.87μM
MAPK2IC50: ~5μM
MAPK1IC50: >5μM
Akt1IC50: >5μM
HER2IC50: 17.1μM


Solubility (25°C) * In vitro DMSO 96 mg/mL (200.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.83 mL 104.17 mL 208.33mL
0.5 mM 4.17 mL 20.83 mL 41.67 mL
1 mM 2.08 mL 10.42 mL 20.83 mL
5 mM 0.42 mL 2.08 mL 4.17 mL

*The above data is based on the productmolecular weight 480.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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