BMS-767778 is a selective DPP4 inhibitor, exhibiting high affinity with Ki values of 0.94 nM for DPP4, and 4.9 nM and 3.2 nM for DPP8 and DPP9, respectively, demonstrating over 3,000-fold selectivity against these related enzymes. This compound also inhibits CYP-3A4 with an IC50 of 5.2 μM. BMS-767778 has been shown to significantly lower blood glucose levels in high-fat diet-induced ob/ob mouse models, indicating its potential for diabetes mellitus research applications.
BMS-767778 is a selective DPP4 inhibitor, exhibiting high affinity with Ki values of 0.94 nM for DPP4, and 4.9 nM and 3.2 nM for DPP8 and DPP9, respectively, demonstrating over 3,000-fold selectivity against these related enzymes. This compound also inhibits CYP-3A4 with an IC50 of 5.2 μM. BMS-767778 has been shown to significantly lower blood glucose levels in high-fat diet-induced ob/ob mouse models, indicating its potential for diabetes mellitus research applications.
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