BMSpep-57 is a competitive macrocyclic peptide inhibitor targeting the PD-1/PD-L1 interaction, exhibiting an IC50 of 7.68 nM. It demonstrates strong binding affinity to PD-L1, with Kd values of 19 nM in Microscale Thermophoresis (MST) and 19.88 nM in Surface Plasmon Resonance (SPR) assays. By disrupting this interaction, BMSpep-57 enhances T cell function, leading to increased IL-2 production in peripheral blood mononuclear cells (PBMCs). This compound is valuable for research applications related to immunotherapy and T cell activation.
BMSpep-57 is a competitive macrocyclic peptide inhibitor targeting the PD-1/PD-L1 interaction, exhibiting an IC50 of 7.68 nM. It demonstrates strong binding affinity to PD-L1, with Kd values of 19 nM in Microscale Thermophoresis (MST) and 19.88 nM in Surface Plasmon Resonance (SPR) assays. By disrupting this interaction, BMSpep-57 enhances T cell function, leading to increased IL-2 production in peripheral blood mononuclear cells (PBMCs). This compound is valuable for research applications related to immunotherapy and T cell activation.
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