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Brexpiprazole is a novel D2 dopamine partial agonist investigational product currently in clinical trials for the treatment of depression, schizophrenia, and attention deficit hyperactivity disorder (ADHD).
Targets
| 5-HT1A | human noradrenergic α1B | Dopamine D2L | 5-HT2A receptors | α2C receptors |
| 0.12 nM(Ki) | 0.17 nM(Ki) | 0.3 nM(Ki) | 0.47 nM(Ki) | 0.59 nM(Ki) |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.06 mL | 115.32 mL | 230.64 mL |
| 0.5 mM | 4.61 mL | 23.06 mL | 46.13 mL |
| 1 mM | 2.31 mL | 11.53 mL | 23.06 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
*The above data is based on the productmolecular weight 433.5733. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A13527 |
|---|---|
| Actions | Agonist |
| M. Wt | 433.5733 |
| Formula | C25H27N3O2S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 913611-97-9 |
| Synonyms | OPC 34712, OPC-34712 |
| SMILES | C1CN(CCN1CCCCOC2=CC3=C(C=C2)C=CC(=O)N3)C4=C5C=CSC5=CC=C4 |
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