BRI-12349 is a dual antagonist of the CysLT1R and CysLT2R receptors, exhibiting Ki values of 1.03 μM and 6.46 μM, respectively. This compound effectively inhibits the production of inositol monophosphate (IP1) induced by leukotriene D4 (LTD4), the primary ligand for cysteinyl leukotrienes. BRI-12349 is a valuable tool for research in immunology and inflammation, particularly in studies related to asthma and other allergic responses.
BRI-12349 is a dual antagonist of the CysLT1R and CysLT2R receptors, exhibiting Ki values of 1.03 μM and 6.46 μM, respectively. This compound effectively inhibits the production of inositol monophosphate (IP1) induced by leukotriene D4 (LTD4), the primary ligand for cysteinyl leukotrienes. BRI-12349 is a valuable tool for research in immunology and inflammation, particularly in studies related to asthma and other allergic responses.
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