Brinazarone is a potent inhibitor of acid lysosomal sphingomyelinase, leading to the accumulation of sphingolipids within cells and resulting in cellular lipidosis. This compound enhances the cytotoxicity of specific immunotherapeutic agents, such as anti-Thy 1.2 AT15E RTA-IT on T2 cells and anti-CD5 T101 on CEM cells. Brinazarone is valuable for research applications involving sphingolipid metabolism and cancer immunotherapy studies.
Brinazarone is a potent inhibitor of acid lysosomal sphingomyelinase, leading to the accumulation of sphingolipids within cells and resulting in cellular lipidosis. This compound enhances the cytotoxicity of specific immunotherapeutic agents, such as anti-Thy 1.2 AT15E RTA-IT on T2 cells and anti-CD5 T101 on CEM cells. Brinazarone is valuable for research applications involving sphingolipid metabolism and cancer immunotherapy studies.
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