BRL-32872 is a potent blocker of the human ether-a-go-go-related gene (hERG) potassium channels, exhibiting an IC50 of 241 nM in isolated cardiomyocytes and 19.8 nM in HEK293 cells. This compound is of particular interest for the study of cardiac arrhythmias, including both atrial and ventricular rhythm disorders. Its ability to inhibit hERG channels makes it a valuable tool for investigating the mechanisms underlying cardiac electrical activity and potential therapeutic interventions.
BRL-32872 is a potent blocker of the human ether-a-go-go-related gene (hERG) potassium channels, exhibiting an IC50 of 241 nM in isolated cardiomyocytes and 19.8 nM in HEK293 cells. This compound is of particular interest for the study of cardiac arrhythmias, including both atrial and ventricular rhythm disorders. Its ability to inhibit hERG channels makes it a valuable tool for investigating the mechanisms underlying cardiac electrical activity and potential therapeutic interventions.
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