BU09059 is a potent and selective antagonist of the kappa-opioid receptor (KOR), displaying a pA2 value of 8.62. It exhibits nanomolar affinity specifically for the κ-receptor, demonstrating 15-fold selectivity over the μ-opioid receptor and 616-fold selectivity over the δ-opioid receptor. BU09059 effectively inhibits U50488-induced antinociception, making it a valuable tool for studying pain pathways and opioid receptor pharmacology. This compound is essential for researchers investigating the role of kappa-opioid receptors in various biological contexts.
BU09059 is a potent and selective antagonist of the kappa-opioid receptor (KOR), displaying a pA2 value of 8.62. It exhibits nanomolar affinity specifically for the κ-receptor, demonstrating 15-fold selectivity over the μ-opioid receptor and 616-fold selectivity over the δ-opioid receptor. BU09059 effectively inhibits U50488-induced antinociception, making it a valuable tool for studying pain pathways and opioid receptor pharmacology. This compound is essential for researchers investigating the role of kappa-opioid receptors in various biological contexts.
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