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BWA-522 intermediate-1

Catalog No.: A80521
Intermediate
BWA-522 intermediate-1 serves as a crucial intermediate in the synthesis of PROTAC BWA-522 and functions as a ligand for cereblon E3 ubiquitin ligase. This compound plays a significant role in the development of orally active small molecule protein-targeting chimeras (PROTACs), which exhibit potent degradation activity on androgen receptor full-length (AR-FL) and variant 7 (AR-V7). Its application is essential in research focused on targeted protein degradation and therapeutic strategies for diseases driven by androgen signaling.
BWA-522 intermediate-1 2241315-66-0 Intermediate
Grouped product items
Size Price Stock Qty
5mg
$20.00
In stock
10mg
$35.00
In stock
25mg
$70.00
In stock
50mg
$105.00
In stock
100mg
$160.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBWA-522 intermediate-1 serves as a crucial intermediate in the synthesis of PROTAC BWA-522 and functions as a ligand for cereblon E3 ubiquitin ligase. This compound plays a significant role in the development of orally active small molecule protein-targeting chimeras (PROTACs), which exhibit potent degradation activity on androgen receptor full-length (AR-FL) and variant 7 (AR-V7). Its application is essential in research focused on targeted protein degradation and therapeutic strategies for diseases driven by androgen signaling.
Product Information
Catalog NumA80521
FormulaC19H19N3O5
Molecular Weight369.37
CAS Number2241315-66-0
SMILESO=CC1CCN(C2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)CC1
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Endocrinology-Hormones > Androgen Receptors