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BWA-522 intermediate-3

Catalog No.: B10773
BWA-522 Intermediate
BWA-522 intermediate-3 is a key intermediate in the synthesis of BWA-522, a small molecule protein-targeting chimera (PROTAC). This compound exhibits potent degradation of androgen receptor full-length (AR-FL) and its variant AR-V7. BWA-522 is primarily used in research applications focusing on hormone-resistant prostate cancer and mechanisms of selective protein degradation.
BWA-522 intermediate-3 3032602-27-7 BWA-522 Intermediate
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBWA-522 intermediate-3 is a key intermediate in the synthesis of BWA-522, a small molecule protein-targeting chimera (PROTAC). This compound exhibits potent degradation of androgen receptor full-length (AR-FL) and its variant AR-V7. BWA-522 is primarily used in research applications focusing on hormone-resistant prostate cancer and mechanisms of selective protein degradation.
Product Information
Catalog NumB10773
FormulaC29H40ClNO5
Molecular Weight518.08
CAS Number3032602-27-7
SMILESCC(C)(C1=CC=C(OC[C@H](O)CCl)C=C1)C2=CC=C(OCC3CCN(C(OC(C)(C)C)=O)CC3)C=C2
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This equation is commonly abbreviated as: C1V1 = C2V2

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Endocrinology-Hormones > Androgen Receptors