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C25-140, a first-in-class, fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.85 mL | 109.27 mL | 218.55 mL |
| 0.5 mM | 4.37 mL | 21.85 mL | 43.71 mL |
| 1 mM | 2.19 mL | 10.93 mL | 21.85 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18705 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 457.57 |
| Formula | C26H31N7O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1358099-18-9 |
| Synonyms | C25140; C-25140; C 25140; C25 140; C25-140; C-25-140; |
| SMILES | O=C(N1CCC(CC2=CC=CC=C2)CC1)CCC3=C(C)N(C4=NN5C(C=C4)=NN=C5C)N=C3C |
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