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C25-140, a first-in-class, fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.
| In vitro | DMSO | 89 mg/mL (194.5 mM) | |
| Water | Insoluble | ||
| Ethanol | 89 mg/mL (194.5 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.85 mL | 109.27 mL | 218.55 mL |
| 0.5 mM | 4.37 mL | 21.85 mL | 43.71 mL |
| 1 mM | 2.19 mL | 10.93 mL | 21.85 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18705 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1358099-18-9 |
| Formula | C26H31N7O |
| M. Wt | 457.57 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | C25140; C-25140; C 25140; C25 140; C25-140; C-25-140; |
| SMILES | O=C(N1CCC(CC2=CC=CC=C2)CC1)CCC3=C(C)N(C4=NN5C(C=C4)=NN=C5C)N=C3C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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