C333H is a selective modulator of PPARγ, effectively exhibiting insulin-sensitizing and hypoglycemic properties. In diabetic mouse models, C333H demonstrates insulin-sensitizing effects comparable to thiazolidinediones without causing significant weight gain or increased adipose tissue mass. The compound elevates levels of high molecular weight adiponectin isoforms in diabetic db/db mice and reduces serine phosphorylation of PPARγ at residue 273 in brown adipose tissue, selectively modulating the expression of specific target genes in adipose tissue. Additionally, C333H shows weak recruitment of co-activators and weak dissociation of co-repressors in vitro, indicating its potential as an inhibitor of type 2 diabetes.
C333H is a selective modulator of PPARγ, effectively exhibiting insulin-sensitizing and hypoglycemic properties. In diabetic mouse models, C333H demonstrates insulin-sensitizing effects comparable to thiazolidinediones without causing significant weight gain or increased adipose tissue mass. The compound elevates levels of high molecular weight adiponectin isoforms in diabetic db/db mice and reduces serine phosphorylation of PPARγ at residue 273 in brown adipose tissue, selectively modulating the expression of specific target genes in adipose tissue. Additionally, C333H shows weak recruitment of co-activators and weak dissociation of co-repressors in vitro, indicating its potential as an inhibitor of type 2 diabetes.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
