Cabozantinib-d6 is a deuterium-labeled derivative of Cabozantinib, a potent inhibitor of multiple receptor tyrosine kinases (RTKs). It effectively targets VEGFR2, c-Met, Kit, Axl, and Flt3, demonstrating IC50 values of 0.035 nM, 1.3 nM, 4.6 nM, 7 nM, and 11.3 nM, respectively. This stable isotope can be utilized in pharmacokinetic studies and metabolism research to trace the compound's path in biological systems, enhancing the understanding of its therapeutic mechanisms.
Cabozantinib-d6 is a deuterium-labeled derivative of Cabozantinib, a potent inhibitor of multiple receptor tyrosine kinases (RTKs). It effectively targets VEGFR2, c-Met, Kit, Axl, and Flt3, demonstrating IC50 values of 0.035 nM, 1.3 nM, 4.6 nM, 7 nM, and 11.3 nM, respectively. This stable isotope can be utilized in pharmacokinetic studies and metabolism research to trace the compound's path in biological systems, enhancing the understanding of its therapeutic mechanisms.
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