Fig. 1 · Structure
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Cabozantinib-d6
Stable Isotope
Cabozantinib-d6 is a deuterium-labeled derivative of Cabozantinib, a potent inhibitor of multiple receptor tyrosine kinases (RTKs). It effectively targets VEGFR2, c-Met, Kit, Axl, and Flt3, demonstrating IC50 values of 0.035 nM, 1.3 nM, 4.6 nM, 7 nM, and 11.3 nM, respectively. This stable isotope can be utilized in pharmacokinetic studies and metabolism research to trace the compound's path in biological systems, enhancing the understanding of its therapeutic mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1802168-46-2 |
| Applications | Stable Isotope |
| Formula | C28H18D6FN3O5 |
| Molecular Weight | 507.54 |
| Synonyms | XL184-d6; BMS-907351-d6 |
| SMILES | C(NC1=CC=C(OC=2C3=C(C=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C3)N=CC2)C=C1)(=O)C4(C(NC5=CC=C(F)C=C5)=O)CC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.