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Biological Activity
CADD522 is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM. CADD522 exhibits antitumor activity.
| In vitro | DMSO | 58 mg/mL (177.82 mM) | |
| Water | Insoluble | ||
| Ethanol | 58 mg/mL (177.82 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.66 mL | 153.29 mL | 306.59 mL |
| 0.5 mM | 6.13 mL | 30.66 mL | 61.32 mL |
| 1 mM | 3.07 mL | 15.33 mL | 30.66 mL |
| 5 mM | 0.61 mL | 3.07 mL | 6.13 mL |
*The above data is based on the productmolecular weight 326.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A19399 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 199735-88-1 |
| Formula | C15H13Cl2NO3 |
| M. Wt | 326.17 |
| Purity | >98% |
| Synonyms | CADD 522, CADD-522 |
| SMILES | ClC1=C(Cl)C=CC(NC(C2C(C3)C=CC3C2C(O)=O)=O)=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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