Camptothecin analog-1

Catalog No.: A57182
Topoisomerase
Camptothecin analog-1 is a potent inhibitor of topoisomerase I, a crucial enzyme involved in DNA replication and repair. This compound demonstrates significant anti-cancer activity by inducing DNA damage and promoting apoptosis in malignant cells. It is used in research to investigate mechanisms of tumorigenesis and explore novel therapeutic strategies in oncology.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCamptothecin analog-1 is a potent inhibitor of topoisomerase I, a crucial enzyme involved in DNA replication and repair. This compound demonstrates significant anti-cancer activity by inducing DNA damage and promoting apoptosis in malignant cells. It is used in research to investigate mechanisms of tumorigenesis and explore novel therapeutic strategies in oncology.
Product Information
Catalog NumA57182
FormulaC23H23FN4O6S
Molecular Weight502.52
CAS Number2873460-51-4
SMILESCS(N(C)CC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC(F)=C(N)C=C51)(=O)=O
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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