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Biological Activity
Cangrelor Tetrasodium is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. It is a modified ATP derivative stable to enzymatic degradation. Unlike clopidogrel (Plavix), which is a prodrug, cangrelor is an active drug not requiring metabolic conversion.
| In vitro | DMSO | 2 mg/mL (2.31 mM) | |
| Water | 87 mg/mL (100.66 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 11.57 mL | 57.85 mL | 115.7 mL |
| 0.5 mM | 2.31 mL | 11.57 mL | 23.14 mL |
| 1 mM | 1.16 mL | 5.79 mL | 11.57 mL |
| 5 mM | 0.23 mL | 1.16 mL | 2.31 mL |
*The above data is based on the productmolecular weight 864.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17919 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 163706-36-3 |
| Formula | C17H21Cl2F3N5Na4O12P3S2 |
| M. Wt | 864.27 |
| Purity | >98% |
| Synonyms | Cangrelor Tetrasodium; AR-C69931MX; AR C69931MX; ARC69931MX |
| SMILES | CSCCNC1=NC(SCCC(F)(F)F)=NC2=C1N=CN2[[email protected]@H]3O[[email protected]](COP([O-])(OP([O-])(C(P([O-])([O-])=O)(Cl)Cl)=O)=O)[[email protected]@H](O)[[email protected]]3O.[Na+].[Na+].[Na+].[Na+] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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