Capecitabine (Xeloda)

Catalog No.: A10177

Capecitabine (Xeloda) Chemical Structure

CAS NO. 154361-50-9

Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-fluorouracil.

Availability: In stock

Package Price Qty
1000 mg
$40.00
5000 mg
$160.00
10mM * 1mL in DMSO
$59.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-fluorouracil.

Targets
Thymidine phosphorylase
In vitro DMSO 72 mg/mL (200.36 mM)
Water 6 mg/mL (16.69 mM)
Ethanol 72 mg/mL (200.36 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.82 mL 139.12 mL 278.24 mL
0.5 mM 5.56 mL 27.82 mL 55.65 mL
1 mM 2.78 mL 13.91 mL 27.82 mL
5 mM 0.56 mL 2.78 mL 5.56 mL

*The above data is based on the productmolecular weight 359.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10177
Actions N/A
M. Wt 359.4
Formula C15H22FN3O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 154361-50-9
Synonyms Captabin
SMILES CCCCCOC(=O)NC1=NC(=O)N(C=C1F)[[email protected]]2[[email protected]@H]([[email protected]@H]([[email protected]](O2)C)O)O

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