CBP/p300-IN-24 is a selective inhibitor of the CBP bromodomain, exhibiting an IC50 of 32 μM and demonstrating notable selectivity over the BRD4 BD-1 bromodomain. This compound interacts with the acetyl lysine binding pocket, establishing hydrogen bonds with Asn1168 and a solvent-mediated hydrogen bond with Tyr1125, alongside hydrophobic interactions with Leu1120, Ile1122, and Val1174. CBP/p300-IN-24 is useful for investigating the role of CBP in various signaling pathways and disease states, particularly in cancer research and epigenetic studies.
CBP/p300-IN-24 is a selective inhibitor of the CBP bromodomain, exhibiting an IC50 of 32 μM and demonstrating notable selectivity over the BRD4 BD-1 bromodomain. This compound interacts with the acetyl lysine binding pocket, establishing hydrogen bonds with Asn1168 and a solvent-mediated hydrogen bond with Tyr1125, alongside hydrophobic interactions with Leu1120, Ile1122, and Val1174. CBP/p300-IN-24 is useful for investigating the role of CBP in various signaling pathways and disease states, particularly in cancer research and epigenetic studies.
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