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CDK/HDAC-IN-1

CDK Inhibitor

CDK/HDAC-IN-1 is a potent inhibitor targeting cyclin-dependent kinases CDK2, CDK4, CDK6, and histone deacetylase 6 (HDAC6) with respective IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM. This dual-action compound demonstrates significant biological activity in inhibiting cell cycle progression and modulating gene expression. CDK/HDAC-IN-1 is suitable for research applications exploring cancer biology, epigenetic regulation, and therapeutic strategies targeting CDK and HDAC pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2762181-73-5
Applications	CDK Inhibitor
Formula	C₂₀H₁₈N₄O₄
Molecular Weight	378.38
SMILES	O=C(/C1=C2NC3=CC=CC=C3C\2=N/OCCCC(NO)=O)NC4=C1C=CC=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.