CDK/HDAC-IN-1 is a potent inhibitor targeting cyclin-dependent kinases CDK2, CDK4, CDK6, and histone deacetylase 6 (HDAC6) with respective IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM. This dual-action compound demonstrates significant biological activity in inhibiting cell cycle progression and modulating gene expression. CDK/HDAC-IN-1 is suitable for research applications exploring cancer biology, epigenetic regulation, and therapeutic strategies targeting CDK and HDAC pathways.
CDK/HDAC-IN-1 is a potent inhibitor targeting cyclin-dependent kinases CDK2, CDK4, CDK6, and histone deacetylase 6 (HDAC6) with respective IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM. This dual-action compound demonstrates significant biological activity in inhibiting cell cycle progression and modulating gene expression. CDK/HDAC-IN-1 is suitable for research applications exploring cancer biology, epigenetic regulation, and therapeutic strategies targeting CDK and HDAC pathways.
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