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CDK2-IN-46

CDK2 Inhibitor

CDK2-IN-46 is a highly selective cyclin-dependent kinase 2 (CDK2) inhibitor with an IC50 value of 0.3 nM. It demonstrates a significant selectivity of over 200-fold compared to other kinases, including CDK1, CDK4, CDK6, CDK7, and CDK9. This compound is valuable for studying cell cycle regulation and has shown improved pharmacokinetic profiles in both rat and cynomolgus monkey models, making it suitable for preclinical research in cancer biology and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2498658-21-0
Applications	CDK2 Inhibitor
Formula	C₂₁H₂₂D₃N₅O₄S
Molecular Weight	446.54
SMILES	O=C1C2(CC2)C3=CN=C(NC4=CC=C(C=C4)S(NC([2H])([2H])[2H])(=O)=O)N=C3N1[C@H]5C[C@@H](CCC5)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.