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CDK4/6-IN-17

CDK4/6 Inhibitor

CDK4/6-IN-17 is a potent orally active inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), exhibiting an IC50 range of 10-100 nM in BE(2) cells. This compound effectively inhibits tumor growth in the COLO205 xenograft model, making it a valuable tool for cancer research focused on cell cycle regulation and therapeutic strategies targeting CDK4/6 pathways. Its application in preclinical studies provides insights into the mechanistic effects of CDK4/6 inhibition on tumor progression.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2035069-96-4
Applications	CDK4/6 Inhibitor
Formula	C₂₇H₂₈F₄N₈
Molecular Weight	540.56
SMILES	FC([C@H]1N2C3=CC(C4=NC(NC5=CC=C(C=N5)CN6CCN(CC6)CC)=NC=C4F)=CC(F)=C3N=C2CC1)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.