CDK

Cat. No.

A19768

CAS No.

2220184-50-7

CDK12-IN-3

CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.

Cat. No.

A19820

CAS No.

1613638-82-6

CDK8-IN-4

CDK8-IN-4 is an inhibitor of CDK8 extracted from patent WO2014090692A1, compound example 16, with an IC50 of 0.2 nM.

Cat. No.

A19829

CAS No.

1884500-15-5

CDK8-IN-3

CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7.

Cat. No.

A19986

CAS No.

1818427-07-4

CDK8/19-IN-1

CDK8/19-IN-1 is a potent, selective and oral bioavailable CDK8/19 dual inhibitor, with IC50s of 0.46 nM, 0.99 nM and 270 nM for CDK8, CDK19 and CDK9, respectively.

Cat. No.

A20040

CAS No.

2118356-96-8

PROTAC CDK9 Degrader-1

PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.

Cat. No.

A20196

CAS No.

2105956-51-0

CDK9-IN-8

CDK9-IN-8 is a highly effective and selective CDK9 inhibitor with an IC50 of 12 nM.

Cat. No.

A20264

CAS No.

444723-13-1

NU6140

NU6140 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs.

Cat. No.

A20318

CAS No.

237430-03-4

Alsterpaullone

Synonyms: 9-Nitropaullone; NSC 705701

Alsterpaullone (9-Nitropaullone;NSC 705701) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively.

Cat. No.

A20392

CAS No.

1330782-76-7

Simurosertib

Synonyms: TAK-931

Simurosertib (TAK-931) is a selective cycle 7 (CDC7) kinase inhibitor, with an IC50

Cat. No.

A20420

CAS No.

890129-26-7

BGG463

Synonyms: K03859

BGG463 (K03859) is an orally active type II CDK2 inhibitor.

Cat. No.

A20512

CAS No.

1070790-89-4

CYC065

Synonyms: Fadraciclib

CYC065 is a second-generation, orally available ATP-competitive inhibitor of CDK2/CDK9 kinases with IC50s of 5 and 26 nM, respectively.

Cat. No.

A20606

CAS No.

1621523-07-6

THZ1-R

THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM.

Cat. No.

A20610

CAS No.

1607837-31-9

CCT-251921

CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor with an IC50 of 2.3 nM.

Cat. No.

A21025

CAS No.

2070015-09-5

NU6300

NU6300 is the first covalent ATP-competitive CDK2 inhibitor.

Cat. No.

A21166

CAS No.

1366002-50-7

Senexin A

Senexin A is a CDK8 inhibitor with an IC50 of 280 nM.

Cat. No.

A21220

CAS No.

1169558-38-6

XL413

XL413 is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM.

Cat. No.

A21385

CAS No.

1000023-05-1

Voruciclib hydrochloride

Voruciclib hydrochloride is a clinical stage orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM.

Cat. No.

A21395

CAS No.

942425-68-5

PHA-767491 hydrochloride

Synonyms: PHA767491; CAY-10572 hydrochloride; CAY10572

PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively.

Cat. No.

A21467

CAS No.

1421693-22-2

Asnuciclib (CDKI-73)

Synonyms: CDKI73; LS-007

CDKI-73 is a potent CDK9 inhibitor with Ki of 4 nM; shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).

Cat. No.

A21485

CAS No.

1609452-30-3

SEL120-34A HCl

SEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.

Cat. No.

A21552

CAS No.

1415559-43-1

CDK9-IN-1

CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection, with an IC50 of 39 nM for CDK9/CycT1, extracted from reference, compound 87.

Cat. No.

A21564

CAS No.

1610358-53-6

(±)-BAY-1251152

Synonyms: BAY-1251152

(±)-BAY-1251152 is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor.

Cat. No.

A21570

CAS No.

1610358-59-2

(-)-BAY-1251152

Synonyms: BAY1251152

(-)-BAY-1251152 is an enanthiomer of BAY-1251152 with rotation (-). BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor.

Cat. No.

A21577

CAS No.

2097938-59-3

Lerociclib dihydrochloride

Synonyms: G1T38 dihydrochloride; G1T 38

Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively.

Cat. No.

A21613

CAS No.

1453834-21-3

LDC4297

LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.