CEP-32496

Catalog No.: A13772

Raf inhibitor

CEP-32496

CEP-32496 Chemical Structure

CAS NO. 1188910-76-0

CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $150.00

Special Price $135.00

10 mg

Regular Price: $250.00

Special Price $225.00

25 mg

Regular Price: $490.00

Special Price $441.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity.
Targets
Target Value
c-KitKd2nM
LCKKd2nM
PDGFRβKd2nM
RETKd2nM
Abl1Kd3nM
VEGFR2Kd8nM
CSF-1RKd9nM
B-Raf(V600E)Kd14nM
EphA2Kd14nM
EGFRKd22nM
B-RafKd36nM
C-RafKd39nM
c-MetKd513nM
JAK2Kd4.7μM
MEK1Kd7.1μM
MEK2Kd8.3μM
JAK1Kd>10μM
JAK3Kd>10μM
ALKKd>10μM
AuroraAKd>10μM
AuroraBKd>10μM
ERK1Kd>10μM
ERK2Kd>10μM
IGF-1RKd>10μM
INSRKd>10μM
PIK3-CAKd>10μM
PIK3-CBKd>10μM
PLK1Kd>10μM
In vitro (25°C) DMSO 9 mg/mL (17.39 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.05 mL 90.27 mL 180.53 mL
0.5 mM 3.61 mL 18.05 mL 36.11 mL
1 mM 1.81 mL 9.03 mL 18.05 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13772
Actions Inhibitor
M. Wt 553.92
Formula C24H23ClF3N5O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1188910-76-0
Synonyms CEP32496, CEP 32496, AC013773, AC 013773, AC-013773
SMILES CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F

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