Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

Catalog No.: A10194

Topoisomerase inhibitor

Cerubidine (Daunorubicin HCl, Rubidomycin HCl)

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) Chemical Structure

CAS NO. 23541-50-6

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $60.00

Special Price $54.00

25 mg

Regular Price: $100.00

Special Price $90.00

50 mg

Regular Price: $160.00

Special Price $144.00

100 mg

Regular Price: $260.00

Special Price $234.00

10mM * 1mL in DMSO

Regular Price: $93.00

Special Price $83.70

Warning WARNING: Attention California Residents: This product can expose you to chemicals including Adriamycin, which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

Targets
DNA synthesis (Cell-free assay)
20 nM(Ki)
In vitro (25°C) DMSO 113 mg/mL (200.36 mM)
Water 113 mg/mL (200.36 mM)
Ethanol 13 mg/mL (23.05 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.73 mL 88.65 mL 177.3 mL
0.5 mM 3.55 mL 17.73 mL 35.46 mL
1 mM 1.77 mL 8.87 mL 17.73 mL
5 mM 0.35 mL 1.77 mL 3.55 mL

*The above data is based on the productmolecular weight 564.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10194
Actions Inhibitor
M. Wt 564.0
Formula C27H29NO10.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 23541-50-6
Synonyms Daunorubicin HCl, Rubidomycin HCl
SMILES C[[email protected]]1[[email protected]]([[email protected]](C[[email protected]@H](O1)O[[email protected]]2C[[email protected]@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl

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