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Cerubidine (Daunorubicin HCl, Rubidomycin HCl) interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. It stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.
Targets
| DNA synthesis (Cell-free assay) | ||||
| 20 nM(Ki) |
| In vitro (25°C) | DMSO | 113 mg/mL (200.36 mM) | |
| Water | 113 mg/mL (200.36 mM) | ||
| Ethanol | 13 mg/mL (23.05 mM) | ||
| In vivo | Saline | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.73 mL | 88.65 mL | 177.3 mL |
| 0.5 mM | 3.55 mL | 17.73 mL | 35.46 mL |
| 1 mM | 1.77 mL | 8.87 mL | 17.73 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.55 mL |
*The above data is based on the productmolecular weight 564.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10194 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 564.0 |
| Formula | C27H29NO10.HCl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 23541-50-6 |
| Synonyms | Daunorubicin HCl, Rubidomycin HCl |
| SMILES | C[[email protected]]1[[email protected]]([[email protected]](C[[email protected]@H](O1)O[[email protected]]2C[[email protected]@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl |
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