CES2-IN-1 is a reversible and selective inhibitor of human carboxylesterase 2 (hCES2), exhibiting an IC50 value of 6.72 μM. This compound effectively reduces CES2 levels in living cells, making it useful for studies involving drug metabolism. CES2-IN-1 has demonstrated efficacy in preclinical models for conditions such as irinotecan-induced delayed diarrhea and dextran sulfate sodium (DSS)-induced ulcerative colitis, supporting its application in gastrointestinal research.
CES2-IN-1 is a reversible and selective inhibitor of human carboxylesterase 2 (hCES2), exhibiting an IC50 value of 6.72 μM. This compound effectively reduces CES2 levels in living cells, making it useful for studies involving drug metabolism. CES2-IN-1 has demonstrated efficacy in preclinical models for conditions such as irinotecan-induced delayed diarrhea and dextran sulfate sodium (DSS)-induced ulcerative colitis, supporting its application in gastrointestinal research.
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