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CGP 56999

Catalog No.: A66892
GABA(B) receptor Antagonist
CGP 56999 is a potent antagonist of the GABA(B) receptor, exhibiting an IC50 value of 0.002 μM. This compound has been demonstrated to elevate brain-derived neurotrophic factor (BDNF) mRNA levels both in vivo and in vitro. CGP 56999 is valuable for research applications focused on neurobiology and the modulation of GABAergic signaling.
CGP 56999 153994-97-9 GABA(B) receptor Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCGP 56999 is a potent antagonist of the GABA(B) receptor, exhibiting an IC50 value of 0.002 μM. This compound has been demonstrated to elevate brain-derived neurotrophic factor (BDNF) mRNA levels both in vivo and in vitro. CGP 56999 is valuable for research applications focused on neurobiology and the modulation of GABAergic signaling.
Product Information
Catalog NumA66892
FormulaC19H30NO5P
Molecular Weight383.42
CAS Number153994-97-9
SMILESO=C(O)C1=CC=CC([C@H](NC[C@H](O)CP(O)(CC2CCCCC2)=O)C)=C1
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Neuronal Signaling > GABA Receptors