CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, exhibiting an IC50 of 6 nM. This compound acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). CGP 78608 hydrochloride is primarily employed in research investigating its anticonvulsant activity and the modulation of excitatory neurotransmission.
CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, exhibiting an IC50 of 6 nM. This compound acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). CGP 78608 hydrochloride is primarily employed in research investigating its anticonvulsant activity and the modulation of excitatory neurotransmission.
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