CH-0793076 is a potent inhibitor of DNA topoisomerase I, exhibiting an IC50 of 2.3 μM. This hexacyclic camptothecin analog serves as both an active drug and a significant metabolite of TP300. CH-0793076 demonstrates efficacy in cells that express the breast cancer resistance protein (BCRP), making it a valuable compound for investigating resistance mechanisms in oncology research.
CH-0793076 is a potent inhibitor of DNA topoisomerase I, exhibiting an IC50 of 2.3 μM. This hexacyclic camptothecin analog serves as both an active drug and a significant metabolite of TP300. CH-0793076 demonstrates efficacy in cells that express the breast cancer resistance protein (BCRP), making it a valuable compound for investigating resistance mechanisms in oncology research.
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