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Catalog No.: A15436

AhR antagonist


CH-223191 Chemical Structure

CAS NO. 301326-22-7

CH-223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor.

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yukiko Sakakibara, .et al. Changes in uridine 5'-diphospho-glucuronosyltransferase 1A6 expression by histone deacetylase inhibitor valproic acid, Biopharm Drug Dispos, 2022, Oct;43(5):175-182 PMID: 36000181
  • Jie Tang, .et al. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) activates Aryl hydrocarbon receptor (AhR) mediated ROS and NLRP3 inflammasome/p38 MAPK pathway inducing necrosis in cochlear hair cells, Ecotoxicol Environ Saf, 2021, Sep 15;221:112423 PMID: 34146985

Biological Activity

CH-223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor.
30 nM
In vitro DMSO 61 mg/mL (182.96 mM)
Water Insoluble
Ethanol Warmed: 4 mg/mL (11.99 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.99 mL 149.97 mL 299.95 mL
0.5 mM 6 mL 29.99 mL 59.99 mL
1 mM 3 mL 15 mL 29.99 mL
5 mM 0.6 mL 3 mL 6 mL

*The above data is based on the productmolecular weight 333.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15436
Actions Antagonist
CAS No. 301326-22-7
Formula C19H19N5O
M. Wt 333.39
Purity >98%
Synonyms CH223191

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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