Chaetocin

Catalog No.: A12812

SUV39H HMT Inhibitor

Chaetocin

Chaetocin Chemical Structure

CAS NO. 28097-03-2

Chaetocin is a histone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 μM). Induces apoptosis in myeloma cell lines in vitro; exhibits antiproliferative activity in a mouse myeloma model in vivo.

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1 mg

Regular Price: $85.00

Special Price $68.00

2 mg

Regular Price: $150.00

Special Price $120.00

5 mg

Regular Price: $300.00

Special Price $240.00

10 mg

Regular Price: $500.00

Special Price $400.00

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Biological Activity

Chaetocin is a histone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 μM). Induces apoptosis in myeloma cell lines in vitro; exhibits antiproliferative activity in a mouse myeloma model in vivo.
Targets
dSU(VAR)3-9 mouse G9a Neurospora crassa DIM5
0.8 μM2.5 μM3 μM
In vitro DMSO Warmed: 87 mg/mL (124.85 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.35 mL 71.75 mL 143.5 mL
0.5 mM 2.87 mL 14.35 mL 28.7 mL
1 mM 1.44 mL 7.18 mL 14.35 mL
5 mM 0.29 mL 1.44 mL 2.87 mL

*The above data is based on the productmolecular weight 696.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12812
Actions Inhibitor
CAS No. 28097-03-2
Formula C30H28N6O6S4
M. Wt 696.84
Purity >98%
SMILES CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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