CHC is a monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas; decreases glycolytic metabolism, migration, and invasion in U251 cells.
Tian Peng, .et al. , World J Gastroenterol, 2024, May 21;30(19):2575-2602 PMID: 38817665
Biological Activity
Description
CHC is a monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas; decreases glycolytic metabolism, migration, and invasion in U251 cells.
Cell Research
Cell Line
Type
Value
Description
References
Product Information
Catalog Num
A13372
Formula
C10H7NO3
Molecular Weight
189.17
CAS Number
28166-41-8
SMILES
C1=CC(=CC=C1/C=C(\C#N)/C(=O)O)O
Synonyms
-Cyano-4-hydroxycinnamic acid
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro
DMSO
32 mg/mL (169.16 mM)
Water
Insoluble
Ethanol
7 mg/mL (37 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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