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- Dong F, .et al. Chimaphilin inhibits human osteosarcoma cell invasion and metastasis through suppressing the TGF-β1-induced epithelial-to-mesenchymal transition markers via PI-3K/Akt, ERK1/2, and Smad signaling pathways, Can J Physiol Pharmacol, 2018, Jan;96(1):1-7 PMID: 28177668
- Wan Daqian, .et al. Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling., Chem Biol Interact., 2015, Jul 25;237:25-30 PMID: 25980584
Biological Activity
Chimaphilin is extracted from pyrola [Passiflora incarnata Fisch.] Chimaphilin could inhibit the viability of MCF-7 cells in a concentration-dependent manner, and the IC50 value was 43.30μM for 24h.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 53.7 mL | 268.51 mL | 537.03 mL |
| 0.5 mM | 10.74 mL | 53.7 mL | 107.41 mL |
| 1 mM | 5.37 mL | 26.85 mL | 53.7 mL |
| 5 mM | 1.07 mL | 5.37 mL | 10.74 mL |
*The above data is based on the productmolecular weight 186.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12031 |
|---|---|
| CAS No. | 482-70-2 |
| Formula | C12H10O2 |
| M. Wt | 186.21 |
| Purity | >98% |
| SMILES | CC1=CC2=C(C=C1)C(=O)C=C(C2=O)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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