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Biological Activity
Chlorprothixene exerts strong antagonism at the following receptors: 5-HT2; D1, D2, D3; H1;mACh; α1-adrenergic.
Targets
Target | Value |
---|---|
D2receptor | ki: 2.96nM |
5-HT6 | ki: 3nM |
H1receptor | ki: 3.75nM |
D3receptor | ki: 4.56nM |
5-HT7 | ki: 5.6nM |
D5receptor | ki: 9nM |
5-HT2 | ki: 9.4nM |
D1receptor | ki: 18nM |
In vitro | DMSO | 5 mg/mL (15.83 mM) | |
Water | Insoluble | ||
Ethanol | 25 mg/mL (79.14 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 31.66 mL | 158.28 mL | 316.56 mL |
0.5 mM | 6.33 mL | 31.66 mL | 63.31 mL |
1 mM | 3.17 mL | 15.83 mL | 31.66 mL |
5 mM | 0.63 mL | 3.17 mL | 6.33 mL |
*The above data is based on the productmolecular weight 315.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10207 |
---|---|
CAS No. | 113-59-7 |
Formula | C18H18ClNS |
M. Wt | 315.9 |
Purity | >98% |
Synonyms | Cloxan, Taractan, Truxal |
SMILES | CN(C)CC/C=C\1/C2=CC=CC=C2SC3=C1C=C(C=C3)Cl |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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