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Biological Activity
Chlorprothixene exerts strong antagonism at the following receptors: 5-HT2; D1, D2, D3; H1;mACh; α1-adrenergic.
Targets
| Target | Value |
|---|---|
| D2receptor | ki: 2.96nM |
| 5-HT6 | ki: 3nM |
| H1receptor | ki: 3.75nM |
| D3receptor | ki: 4.56nM |
| 5-HT7 | ki: 5.6nM |
| D5receptor | ki: 9nM |
| 5-HT2 | ki: 9.4nM |
| D1receptor | ki: 18nM |
| In vitro | DMSO | 5 mg/mL (15.83 mM) | |
| Water | Insoluble | ||
| Ethanol | 25 mg/mL (79.14 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.66 mL | 158.28 mL | 316.56 mL |
| 0.5 mM | 6.33 mL | 31.66 mL | 63.31 mL |
| 1 mM | 3.17 mL | 15.83 mL | 31.66 mL |
| 5 mM | 0.63 mL | 3.17 mL | 6.33 mL |
*The above data is based on the productmolecular weight 315.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10207 |
|---|---|
| CAS No. | 113-59-7 |
| Formula | C18H18ClNS |
| M. Wt | 315.9 |
| Purity | >98% |
| Synonyms | Cloxan, Taractan, Truxal |
| SMILES | CN(C)CC/C=C\1/C2=CC=CC=C2SC3=C1C=C(C=C3)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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