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Biological Activity
CI 976 is a trimethoxy fatty acid anilide inhibitor of liver and intestinal acyl coenzyme A cholesterol acyltransferase (ACAT) and sterol O-acyltransferase (SOAT). Cl 976 lowers non-high density lipoprotein (non-HDL) cholesterol and increases HDL-cholesterol concentrations.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.41 mL | 127.04 mL | 254.08 mL |
| 0.5 mM | 5.08 mL | 25.41 mL | 50.82 mL |
| 1 mM | 2.54 mL | 12.7 mL | 25.41 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
*The above data is based on the productmolecular weight 393.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16370 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 114289-47-3 |
| Formula | C23H39NO4 |
| M. Wt | 393.57 |
| Purity | >98% |
| Synonyms | PD 128042, PD128042, PD-128042, CI976, CI-976 |
| SMILES | O=C(C(C)(C)CCCCCCCCCC)NC(C(OC)=CC(OC)=C1)=C1OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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