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Dibucaine (USAN) is an amide local anesthetic. Dibucaine reversibly binds to and inactivates sodium channels in the neuronal cell membrane. Inhibition of sodium channels prevents the depolarization of nerve cell membranes and inhibits subsequent propagation of impulses along the course of the nerve, thereby limiting the excitation of nerve endings. This results in loss of sensation.
| In vitro | DMSO | 59 mg/mL (171.78 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.12 mL | 145.58 mL | 291.15 mL |
| 0.5 mM | 5.82 mL | 29.12 mL | 58.23 mL |
| 1 mM | 2.91 mL | 14.56 mL | 29.12 mL |
| 5 mM | 0.58 mL | 2.91 mL | 5.82 mL |
*The above data is based on the productmolecular weight 343.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17672 |
|---|---|
| CAS No. | 85-79-0 |
| Formula | C20H29N3O2 |
| M. Wt | 343.46 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | Dibucaine; Cinchocaine; Nupercainal; Nupercaine; Sovcaine; Dibucaine Base |
| SMILES | CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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