cis-4-Br-2,5-F2-PCPA is a selective inhibitor of lysine-specific demethylase 1 (LSD1), demonstrating a Ki value of 94 nM for LSD1 compared to 8.4 μM for LSD2. This compound effectively inhibits LSD1 activity, resulting in reduced proliferation of cancer stem cells by increasing the levels of dimethylated histone H3 at lysine 4 (H3K4) in CCRF-CEM cells. Its selective action makes cis-4-Br-2,5-F2-PCPA a valuable tool for research on epigenetic regulation and cancer biology.
cis-4-Br-2,5-F2-PCPA is a selective inhibitor of lysine-specific demethylase 1 (LSD1), demonstrating a Ki value of 94 nM for LSD1 compared to 8.4 μM for LSD2. This compound effectively inhibits LSD1 activity, resulting in reduced proliferation of cancer stem cells by increasing the levels of dimethylated histone H3 at lysine 4 (H3K4) in CCRF-CEM cells. Its selective action makes cis-4-Br-2,5-F2-PCPA a valuable tool for research on epigenetic regulation and cancer biology.
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