CL-184005 is a potent platelet-activating factor (PAF) antagonist that effectively inhibits PAF-induced platelet aggregation, with IC50 values of 600 nM and 510 nM in human and rabbit platelet-rich plasma, respectively. This compound has demonstrated protective effects against endotoxin-induced gastrointestinal damage and hypotension in rat models. Additionally, CL-184005 shows promise in mitigating the effects of Gram-negative bacterial sepsis, making it a valuable tool for research in inflammatory and infectious disease models.
CL-184005 is a potent platelet-activating factor (PAF) antagonist that effectively inhibits PAF-induced platelet aggregation, with IC50 values of 600 nM and 510 nM in human and rabbit platelet-rich plasma, respectively. This compound has demonstrated protective effects against endotoxin-induced gastrointestinal damage and hypotension in rat models. Additionally, CL-184005 shows promise in mitigating the effects of Gram-negative bacterial sepsis, making it a valuable tool for research in inflammatory and infectious disease models.
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