CL-387785 (EKI-785)

Catalog No.: A13146

EGFR inhibitor

CL-387785 (EKI-785)

CL-387785 (EKI-785) Chemical Structure

CAS NO. 194423-06-8

CL-387785 is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.

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10 mg

Regular Price: $120.00

Special Price $96.00

25 mg

Regular Price: $250.00

Special Price $200.00

50 mg

Regular Price: $450.00

Special Price $360.00

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Biological Activity

CL-387785 is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.
Targets
EGFR
370 pM
In vitro DMSO Warmed: 61 mg/mL (160 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.23 mL 131.15 mL 262.31 mL
0.5 mM 5.25 mL 26.23 mL 52.46 mL
1 mM 2.62 mL 13.12 mL 26.23 mL
5 mM 0.52 mL 2.62 mL 5.25 mL

*The above data is based on the productmolecular weight 381.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13146
Actions Inhibitor
CAS No. 194423-06-8
Formula C18H13BrN4O
M. Wt 381.23
Purity >98%
Synonyms WAY-EKI 785, CL387785, CL 387785, EKI785, WAY-EKI785, EKI 785, EKI-785
SMILES CC#C/C(O)=N/C1=CC(C(NC2=CC=CC(Br)=C2)=NC=N3)=C3C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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