CL2A is a cleavable linker designed for antibody-drug conjugates (ADCs), incorporating PEG8 and a triazole structure within a PABC-peptide framework. This linker exhibits pH sensitivity, facilitating a bystander effect upon cleavage and forming a disulfide bond with cysteine residues on antibodies. CL2A is suitable for research applications focused on optimizing ADC formulations and enhancing therapeutic efficacy through targeted delivery mechanisms.
CL2A is a cleavable linker designed for antibody-drug conjugates (ADCs), incorporating PEG8 and a triazole structure within a PABC-peptide framework. This linker exhibits pH sensitivity, facilitating a bystander effect upon cleavage and forming a disulfide bond with cysteine residues on antibodies. CL2A is suitable for research applications focused on optimizing ADC formulations and enhancing therapeutic efficacy through targeted delivery mechanisms.
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