CL2A

Catalog No.: A18396

CL2A

CL2A Chemical Structure

CAS NO. 1846605-04-6

L2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.

Availability: In stock

Package Price Qty
1 mg
$320.00
5 mg
$960.00
10 mg
$1,600.00
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Biological Activity

L2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 9.04 mL 45.2 mL 90.4 mL
0.5 mM 1.81 mL 9.04 mL 18.08 mL
1 mM 0.9 mL 4.52 mL 9.04 mL
5 mM 0.18 mL 0.9 mL 1.81 mL

*The above data is based on the productmolecular weight 1106.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18396
CAS No. 1846605-04-6
Formula C51H79N9O18
M. Wt 1106.22
Purity >98%
SMILES O=C(NC1=CC=C(COC(O)=O)C=C1)[[email protected]](CCCCN)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN2N=NC(CNC(C3CCC(CN4C(C=CC4=O)=O)CC3)=O)=C2)=O)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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