Cladribine

Catalog No.: A10223

Cladribine Chemical Structure

CAS NO. 4291-63-8

Cladribine is a synthetic anti-cancer agent that mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, which interferes with the cell's ability to process DNA.

Availability: In stock

Package Price Qty
25 mg
$45.00
50 mg
$70.00
100 mg
$120.00
200 mg
$200.00
10mM * 1mL in DMSO
$64.00
Warning WARNING: Attention California Residents: This product can expose you to chemicals including Adriamycin, which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Cladribine is a synthetic anti-cancer agent that mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, which interferes with the cell's ability to process DNA.
Targets
Adenosine deaminase (MM1.S cells) Adenosine deaminase (RPMI8226 cells) Adenosine deaminase (U266 cells)
0.18 μM0.75 μM2.43 μM
In vitro DMSO 57 mg/mL (199.51 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35 mL 175.01 mL 350.02 mL
0.5 mM 7 mL 35 mL 70 mL
1 mM 3.5 mL 17.5 mL 35 mL
5 mM 0.7 mL 3.5 mL 7 mL

*The above data is based on the productmolecular weight 285.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10223
Actions N/A
M. Wt 285.7
Formula C10H12ClN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 4291-63-8
Synonyms 2-chlorodeoxyadenosine, Leustatin
SMILES C1[[email protected]@H]([[email protected]](O[[email protected]]1N2C=NC3=C2N=C(N=C3N)Cl)CO)O

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