CNX-2006

Catalog No.: A13755

EGFR inhibitor

CNX-2006

CNX-2006 Chemical Structure

CAS NO. 1375465-09-0

CNX-2006 is a potent, mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the prototype for CO-1686, which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer.

Availability: In stock

Package Price Qty
10 mg
$180.00
25 mg
$350.00
50 mg
$600.00
100 mg
$1,000.00
10mM * 1mL in DMSO
$157.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

CNX-2006 is a potent, mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the prototype for CO-1686, which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer.
In vitro DMSO 100 mg/mL (183.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol 29 mg/mL (53.15 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.33 mL 91.65 mL 183.31 mL
0.5 mM 3.67 mL 18.33 mL 36.66 mL
1 mM 1.83 mL 9.17 mL 18.33 mL
5 mM 0.37 mL 1.83 mL 3.67 mL

*The above data is based on the productmolecular weight 545.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13755
Actions Inhibitor
M. Wt 545.53
Formula C26H27F4N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1375465-09-0
Synonyms CNX2006, CNX 2006
SMILES COC1=C(C=CC(=C1)NC2CN(C2)CCF)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F

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