CNX-2006

Catalog No.: A13755

EGFR inhibitor

CNX-2006

CNX-2006 Chemical Structure

CAS NO. 1375465-09-0

CNX-2006 is a potent, mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the prototype for CO-1686, which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $180.00

Special Price $144.00

25 mg

Regular Price: $350.00

Special Price $280.00

50 mg

Regular Price: $600.00

Special Price $480.00

100 mg

Regular Price: $1,000.00

Special Price $800.00

10mM * 1mL in DMSO

Regular Price: $157.00

Special Price $125.60

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Biological Activity

CNX-2006 is a potent, mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the prototype for CO-1686, which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer.
In vitro DMSO 90 mg/mL (164.97 mM)
Water Insoluble
Ethanol 26 mg/mL (47.65 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.33 mL 91.65 mL 183.31 mL
0.5 mM 3.67 mL 18.33 mL 36.66 mL
1 mM 1.83 mL 9.17 mL 18.33 mL
5 mM 0.37 mL 1.83 mL 3.67 mL

*The above data is based on the productmolecular weight 545.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13755
Actions Inhibitor
CAS No. 1375465-09-0
Formula C26H27F4N7O2
M. Wt 545.53
Purity >98%
Synonyms CNX2006, CNX 2006
SMILES COC1=C(C=CC(=C1)NC2CN(C2)CCF)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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