CO-1686 (Rociletinib, AVL-301)

Name: CO-1686 (Rociletinib, AVL-301)
Brand: Adooq Bioscience
SKU: A13028
Rating: 100 (268 reviews)

Catalog No.: A13028

EGFR inhibitor

CO-1686 (Rociletinib, AVL-301) Chemical Structure

CAS NO. 1374640-70-6

CO-1686 is a novel, oral, targeted covalent (irreversible) inhibitor of the cancer-causing mutant forms of epidermal growth factor receptor (EGFR) currently being studied for the treatment of non-small cell lung cancer (NSCLC).

Availability: In stock

Package	Price	Qty
5 mg	$50.00
10 mg	$80.00
25 mg	$130.00
50 mg	$160.00
10mM * 1mL in DMSO	$148.00
Custom Size	Get quote

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Biological Activity

Solubility *

In vitro (25°C)	DMSO	91 mg/mL (163.8 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18 mL	90 mL	180 mL
0.5 mM	3.6 mL	18 mL	36 mL
1 mM	1.8 mL	9 mL	18 mL
5 mM	0.36 mL	1.8 mL	3.6 mL

*The above data is based on the productmolecular weight 555.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A13028
Actions	Inhibitor
CAS No.	1374640-70-6
Formula	C27H28F3N7O3
M. Wt	555.55
Purity	>98%
Synonyms	CO1686; AVL-301; CNX-419 ;AVL 301; AVL301; CNX419
SMILES	CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.