Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix.
Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix.
Targets
Target
Value
Product Information
Catalog Num
A18573
Formula
C14H11NO4
Molecular Weight
257.24
CAS Number
328565-16-8
SMILES
O=CC1=CC(CC2=CC=CC=C2)=CC([N+]([O-])=O)=C1O
Synonyms
Col 003, Col-003
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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