Colibactin 742 is a potent DNA alkylator and crosslinker inducer that covalently targets DNA, exhibiting an IC50 of 5.2 μM in human cervical cancer cells (HeLa). This compound forms interstrand crosslinks, thereby activating the Fanconi anemia DNA repair pathway and promoting the formation of γH2AX and FANCD2 foci, which can lead to cell cycle arrest. Colibactin 742 serves as a valuable tool for investigations into colorectal cancer, microbial tumorigenesis, DNA damage repair mechanisms, and the study of mutation signatures, effectively mimicking the genotoxic effects of natural Colibactin while providing enhanced stability.
Colibactin 742 is a potent DNA alkylator and crosslinker inducer that covalently targets DNA, exhibiting an IC50 of 5.2 μM in human cervical cancer cells (HeLa). This compound forms interstrand crosslinks, thereby activating the Fanconi anemia DNA repair pathway and promoting the formation of γH2AX and FANCD2 foci, which can lead to cell cycle arrest. Colibactin 742 serves as a valuable tool for investigations into colorectal cancer, microbial tumorigenesis, DNA damage repair mechanisms, and the study of mutation signatures, effectively mimicking the genotoxic effects of natural Colibactin while providing enhanced stability.
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