COR628 is a positive allosteric modulator of GABA(B) receptors, enhancing GABA-induced GTPγS stimulation. It demonstrates significant activity in vitro and has shown efficacy in mouse models by potentiating sedation and hypnosis induced by baclofen, leading to reduced onset time and prolonged loss of righting reflex. Additionally, COR628 exhibits a cytotoxic effect comparable to or greater than that of other known modulators, making it a valuable tool for research on GABAergic signaling and its implications in neurological studies.
COR628 is a positive allosteric modulator of GABA(B) receptors, enhancing GABA-induced GTPγS stimulation. It demonstrates significant activity in vitro and has shown efficacy in mouse models by potentiating sedation and hypnosis induced by baclofen, leading to reduced onset time and prolonged loss of righting reflex. Additionally, COR628 exhibits a cytotoxic effect comparable to or greater than that of other known modulators, making it a valuable tool for research on GABAergic signaling and its implications in neurological studies.
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