CP-195543 is a selective, orally active antagonist of the leukotriene B4 (LTB4) receptor, exhibiting IC50 values of 6.8 nM in human neutrophils and 37.0 nM in murine spleen membranes. This compound effectively inhibits CD11b up-regulation and prevents LTB4-mediated neutrophil infiltration. CP-195543 is valuable for research applications focused on inflammatory responses and neutrophil activity.
CP-195543 is a selective, orally active antagonist of the leukotriene B4 (LTB4) receptor, exhibiting IC50 values of 6.8 nM in human neutrophils and 37.0 nM in murine spleen membranes. This compound effectively inhibits CD11b up-regulation and prevents LTB4-mediated neutrophil infiltration. CP-195543 is valuable for research applications focused on inflammatory responses and neutrophil activity.
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