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- Yu Muta, .et al. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine, Nat Commun, 2018, 9: 2174 PMID: 29872037
- Gina M. Sizemore, .et al. Stromal PTEN determines mammary epithelial response to radiotherapy, Nat Commun, 2018, 9: 2783 PMID: 30018330
Biological Activity
CP-724714 is an orally available, small molecule, potent HER-2 tyrosine kinase inhibitor that inhibits HER2 kinase (IC50 3.8 ng/ml) .
Targets
HER2/ErbB2 (Cell-free assay) | ||||
10 nM |
In vitro (25°C) | DMSO | 83 mg/mL (176.77 mM) | |
Water | Insoluble | ||
Ethanol | 83 mg/mL (176.77 mM) | ||
In vivo | 0.5% methylcellulose | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.3 mL | 106.5 mL | 212.99 mL |
0.5 mM | 4.26 mL | 21.3 mL | 42.6 mL |
1 mM | 2.13 mL | 10.65 mL | 21.3 mL |
5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
*The above data is based on the productmolecular weight 469.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10242 |
---|---|
Actions | Inhibitor |
CAS No. | 537705-08-1, 383432-38-0 |
Formula | C27H27N5O3 |
M. Wt | 469.5 |
Purity | >98% |
Synonyms | CP724714 |
SMILES | CC1=NC=C(C=C1)OC2=C(C=C(C=C2)NC3=NC=NC4=C3C=C(C=C4)C=CCNC(=O)COC)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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