CP-724714

Name: CP-724714
Brand: Adooq Bioscience
SKU: A10242
Rating: 100 (2 reviews)

Catalog No.: A10242

HER2/ErbB2 inhibitor

Product Citations (2)

CP-724714 Chemical Structure

CAS NO. 537705-08-1, 383432-38-0

CP-724714 is an orally available, small molecule, potent HER-2 tyrosine kinase inhibitor that inhibits HER2 kinase (IC50 3.8 ng/ml) .

Availability: In stock

Package	Price	Qty
5 mg	$60.00
10 mg	$100.00
25 mg	$230.00
50 mg	$400.00
10mM * 1mL in DMSO	$115.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq CP-724714

Yu Muta, .et al. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine, Nat Commun, 2018, 9: 2174 PMID: 29872037
Gina M. Sizemore, .et al. Stromal PTEN determines mammary epithelial response to radiotherapy, Nat Commun, 2018, 9: 2783 PMID: 30018330

Biological Activity

CP-724714 is an orally available, small molecule, potent HER-2 tyrosine kinase inhibitor that inhibits HER2 kinase (IC50 3.8 ng/ml) .

Targets

HER2/ErbB2 (Cell-free assay)
10 nM

Solubility *

In vitro (25°C)	DMSO	83 mg/mL (176.77 mM)
	Water	Insoluble
	Ethanol	83 mg/mL (176.77 mM)
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.3 mL	106.5 mL	212.99 mL
0.5 mM	4.26 mL	21.3 mL	42.6 mL
1 mM	2.13 mL	10.65 mL	21.3 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

*The above data is based on the productmolecular weight 469.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10242
Actions	Inhibitor
CAS No.	537705-08-1, 383432-38-0
Formula	C27H27N5O3
M. Wt	469.5
Purity	>98%
Synonyms	CP724714
SMILES	CC1=NC=C(C=C1)OC2=C(C=C(C=C2)NC3=NC=NC4=C3C=C(C=C4)C=CCNC(=O)COC)C
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.