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CP-724714

Catalog No.: A10242

HER2/ErbB2 inhibitor

CP-724714

CP-724714 Chemical Structure

CAS NO. 537705-08-1, 383432-38-0

CP-724714 is an orally available, small molecule, potent HER-2 tyrosine kinase inhibitor that inhibits HER2 kinase (IC50 3.8 ng/ml) .

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$100.00
25 mg
$230.00
50 mg
$400.00
10mM * 1mL in DMSO
$115.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yu Muta, .et al. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine, Nat Commun, 2018, 9: 2174 PMID: 29872037
  • Gina M. Sizemore, .et al. Stromal PTEN determines mammary epithelial response to radiotherapy, Nat Commun, 2018, 9: 2783 PMID: 30018330

Biological Activity

CP-724714 is an orally available, small molecule, potent HER-2 tyrosine kinase inhibitor that inhibits HER2 kinase (IC50 3.8 ng/ml) .
Targets
HER2/ErbB2 (Cell-free assay)
10 nM
In vitro (25°C) DMSO 83 mg/mL (176.77 mM)
Water Insoluble
Ethanol 83 mg/mL (176.77 mM)
In vivo 0.5% methylcellulose 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.5 mL 212.99 mL
0.5 mM 4.26 mL 21.3 mL 42.6 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10242
Actions Inhibitor
CAS No. 537705-08-1, 383432-38-0
Formula C27H27N5O3
M. Wt 469.5
Purity >98%
Synonyms CP724714
SMILES CC1=NC=C(C=C1)OC2=C(C=C(C=C2)NC3=NC=NC4=C3C=C(C=C4)C=CCNC(=O)COC)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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