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Biological Activity
CPI-1205 is a highly potent (biochemical IC50 = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of EZH2.
| In vitro | DMSO | 90 mg/mL (173.55 mM) | |
| Water | Insoluble | ||
| Ethanol | 90 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.28 mL | 96.42 mL | 192.84 mL |
| 0.5 mM | 3.86 mL | 19.28 mL | 38.57 mL |
| 1 mM | 1.93 mL | 9.64 mL | 19.28 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
*The above data is based on the productmolecular weight 518.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16357 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1621862-70-1 |
| Formula | C27H33F3N4O3 |
| M. Wt | 518.57 |
| Purity | >98% |
| Synonyms | CPI 1205, CPI1205 |
| SMILES | CC1=CC(OC)=C(CNC(C2=C(C)N([[email protected]](C)C3CCN(CC(F)(F)F)CC3)C4=C2C=CC=C4)=O)C(N1)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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