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Biological Activity
CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
Targets
| EZH2 WT | EZH2 Y641N | EZH1 | ||
| 0.24 nM | 0.51 nM | 6.1 nM |
| In vitro (25°C) | DMSO | 88 mg/mL (166.45 mM) | |
| Water | Insoluble | ||
| Ethanol | 88 mg/mL (166.45 mM) | ||
| In vivo | 10% DMSO+60% PEG 400+30% ddH2O | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.92 mL | 94.58 mL | 189.16 mL |
| 0.5 mM | 3.78 mL | 18.92 mL | 37.83 mL |
| 1 mM | 1.89 mL | 9.46 mL | 18.92 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
*The above data is based on the productmolecular weight 528.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15920 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1450655-76-1 |
| Formula | C27H36N4O5S |
| M. Wt | 528.66 |
| Purity | >98% |
| Synonyms | CPI 169, CPI169 |
| SMILES | CCS(N1CCC([[email protected]@](N2C(C)=C(/C(O)=N/CC(C(O)=N3)=C(OC)C=C3C)C4=CC=CC=C42)([H])C)CC1)(=O)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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