CPI-169

Catalog No.: A15920

EZH2 inhibitor

CPI-169

CPI-169 Chemical Structure

CAS NO. 1450655-76-1

CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$180.00
25 mg
$420.00
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Biological Activity

CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
Targets
EZH2 WT EZH2 Y641N EZH1
0.24 nM0.51 nM6.1 nM
In vitro (25°C) DMSO 88 mg/mL (166.45 mM)
Water Insoluble
Ethanol 88 mg/mL (166.45 mM)
In vivo 10% DMSO+60% PEG 400+30% ddH2O 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.92 mL 94.58 mL 189.16 mL
0.5 mM 3.78 mL 18.92 mL 37.83 mL
1 mM 1.89 mL 9.46 mL 18.92 mL
5 mM 0.38 mL 1.89 mL 3.78 mL

*The above data is based on the productmolecular weight 528.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15920
Actions Inhibitor
CAS No. 1450655-76-1
Formula C27H36N4O5S
M. Wt 528.66
Solubility DMSO
Purity >98%
Synonyms CPI 169, CPI169
SMILES CCS(N1CCC([[email protected]@](N2C(C)=C(/C(O)=N/CC(C(O)=N3)=C(OC)C=C3C)C4=CC=CC=C42)([H])C)CC1)(=O)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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